The formation of multicellular organisms requires concerted action by cells, which alter their adhesive and migratory behaviors. Cell adhesion and migration are tightly regulated by intra- and extracellular signals, which are conveyed through the cellular membrane by specialized receptors known as integrins.[1] Integrins are the starting point of a variety of signaling cascades and are involved in a multitude of physiological events important to multicellular organism morphogenesis, ranging from cell adhesion to migration, apoptosis, and angiogenesis as well as pathophysiological behaviors such as those found in cancer metastasis.[2] The transmembrane (TM) domains of integrins are at the center of integrin signaling.[3] Recently, a structure of the TM domains of the aIIbb3 integrin has been reported that sheds light on the signal transduction mechanism of integrins.[4–7]