Interleukins in cancer: from biology to therapy
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours
The SARS‐unique domain (SUD) of SARS‐CoV and SARS‐CoV‐2 interacts with human Paip1 to enhance viral RNA translation
Loss‑of‑function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML
FUS-dependent liquid–liquid phase separation is important for DNA repair initiation
Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals
Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells
A protein assembly mediates Xist localization and gene silencing
Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma
Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation
Systematic analysis of the binding behaviourof UHRF1 towards different methyl- and carboxylcytosine modification patterns at CpG dyads
Tunable light and drug induced depletion of target proteins
NAIL-MS reveals the repair of 2-methylthiocytidine by AlkB in E. coli
Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans
Liquid-crystalline phase transitions in lipid droplets are related to cellular states and specific organelle association
A unified multi-kingdom Golden Gate cloning platform
Ethynylphosphonamidates for the rapid and cysteine selective generation of efficacious Antibody‐Drug‐Conjugates
Loss of KDM6A confers drug resistance in acute myeloid leukemia
Restriction of AID activity and somatic hypermutation by PARP-1
Switching the Post-translational Modification of Translation Elongation Factor EF-P
A conserved RNA seed‐pairing domain directs small RNA‐mediated stress resistance in enterobacteria
Extension of the minimal functional unit of the RNA polymerase II CTD from yeast to mammalian cells
KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells
Phenotypic Heterogeneity Generated by Histidine Kinase-Based Signaling Networks
TuPPL: Tub-tag mediated C-terminal protein–protein-ligation using complementary click-chemistry handles
Cysteine‐selective phosphonamidate electrophiles for modular protein bioconjugations
Importance of Pyruvate Sensing and Transport for the Resuscitation of Viable but Nonculturable Escherichia coli K-12
Three autoinducer molecules act in concert to control virulence gene expression in Vibrio cholerae
DNA-binding directs the localization of a membrane-integrated receptor of the ToxR family
Noncanonical CTD kinases regulate RNA polymerase II in a gene-class-specific manner
MIR sequences recruit zinc finger protein ZNF768 to expressed genes
Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription
LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells
Genome-wide Rules of Nucleosome Phasing in Drosophila
Genome organization and DNA accessibility control antigenic variation in trypanosomes
MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms
Genome-wide measurement of local nucleosome array regularity and spacing by nanopore sequencing
DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex
The role of polyproline motifs in the histidine kinase EnvZ
Dying cells expose a nuclear antigen cross-reacting with anti-PD-1 monoclonal antibodies
Bacterial transmembrane signalling systems and their engineering for biosensing
Outer Membrane Vesicles Facilitate Trafficking of the Hydrophobic Signaling Molecule CAI-1 between Vibrio harveyi Cells
Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut
CHRAC/ACF contribute to the repressive ground state of chromatin
Evolutionary analysis of polyproline motifs in Escherichia coli reveals their regulatory role in translation
Genome-wide analysis of PDX1 target genes in human pancreatic progenitors
Phosphorylation of the outer membrane mitochondrial protein OM64 influences protein import into mitochondria
Toward dynamic structural biology: Two decades of single-molecule Förster resonance energy transfer
Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA
Reproducibility in Cancer Biology: Getting to grips with c-Myc
Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals
Nanobodies: Chemical Functionalization Strategies and Intracellular Applications
Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells
Ubiquitome Analysis Reveals PCNA-Associated Factor 15 (PAF15) as a Specific Ubiquitination Target of UHRF1 in Embryonic Stem Cells
A Poly-ADP-Ribose TriggerReleases the Auto-Inhibitionof a Chromatin Remodeling Oncogene
Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization
Cancer cells induce interleukin-22 production from memory CD4+ T cells via interleukin-1 to promote tumor growth
BtsT, a Novel and Specific Pyruvate/H+ Symporter in Escherichia coli
A Single-Cell View of the BtsSR/YpdAB Pyruvate Sensing Network in Escherichia coli and Its Biological Relevance
CDK9-dependent RNA polymerase II pausing controls transcription initiation
MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption
Structural Basis for EarP-Mediated Arginine Glycosylation of Translation Elongation Factor EF-P
Leaderless secreted peptide signaling molecule alters global gene expression and increases virulence of a human bacterial pathogen
cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders
PP32 and SET/TAF-Iβ proteins regulate the acetylation of newly synthesized histone H4
Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation
Comparative analysis of LytS/LytTR-type histidine kinase/response regulator systems in γ-proteobacteria
Chromosome topology guides the Drosophila Dosag eCompensation Complex for target gene activation
Non-canonical activation of histidine kinase KdpD by phosphotransferase protein PtsN through interaction with the transmitter domain
Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells
Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation
Identification of the elementary structural units of the DNA damage response
Chimeric PD-1:28 receptor upgrades low-avidity T cells and restores effector function of tumor-infiltrating lymphocytes for adoptive cell therapy
Ubiquitylation of the acetyltransferase MOF in Drosophila melanogaster
Transcriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of small molecule inhibitor JQ1
Identification of a High-Affinity Pyruvate Receptor in Escherichia coli
Different phosphoisoforms of RNA polymerase II engage the Rtt103 termination factor in a structurally analogous manner
MacroH2A histone variants maintain nuclear organization and heterochromatin architecture
Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator
Activity, Abundance, and Localization of Quorum Sensing Receptors in Vibrio harveyi
Quantitative 3D structured illumination microscopy of nuclear structures
Remodelers tap into nucleosome plasticity
TOM9.2 Is a Calmodulin-Binding Protein Critical for TOM Complex Assembly but Not for Mitochondrial Protein Import in Arabidopsis thaliana
Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling
Adrenergic Signaling Strengthens Cardiac Myocyte Cohesion
DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation
The Drosophila speciation factor HMR localizes to genomic insulator sites
CipA and CipB as Scaffolds To Organize Proteins into Crystalline Inclusions
Comparative Analysis of Single-Cell RNA Sequencing Methods
Silencing of endogenous retroviruses by heterochromatin
The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity
Insulation and wiring specificity of BceR-like response regulators and their target promoters in Bacillus subtilis
Revisiting regulation of potassium homeostasis in Escherichia coli: the connection to phosphate limitation
Intracellular Delivery of Nanobodies for Imaging of Target Proteins in Live Cells
Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration
KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1
The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage
Nick Your DNA, Mark Your Chromatin
sNASP and ASF1A function through both competitive and compatible modes of histone binding
Determination of local chromatin composition by CasID
TetraMabs: simultaneous targeting of four oncogenic receptor tyrosine kinases for tumor growth inhibition in heterogeneous tumor cell populations
PionX sites mark the X chromosome for dosage compensation
Mechanistic analysis of aliphatic β-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action
Splice variants of the SWR1-type nucleosome remodeling factor Domino have distinct functions during Drosophila melanogaster oogenesis
Synthesis and Macrodomain Binding of Mono-ADP-Ribosylated Peptides
Production of Small Non-coding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster
p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1
CENPs and Sweet Nucleosomes Face the FACT
Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability
Resolving the α-glycosidic linkage of arginine-rhamnosylated translation elongation factor P triggers generation of the first ArgRha specific antibody
Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases
A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination
H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex
Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells
A Dual-Sensing Receptor Confers Robust Cellular Homeostasis
Getting Access to Low-Complexity Domain Modifications
Specific threonine-4 phosphorylation and function of RNA polymerase II CTD during M phase progression
The Metabolic Impact on Histone Acetylation and Transcription in Ageing
A novel TLR7 agonist reverses NK cell anergy and cures RMA-S lymphoma-bearing mice
Identification and Initial Characterization of Prophages in Vibrio campbellii
Comparison of Intranasal Outer Membrane Vesicles with Cholera Toxin and Injected MF59C.1 as Adjuvants for Malaria Transmission Blocking Antigens AnAPN1 and Pfs48/45
Cross-species analyses unravel the complexity of H3K27me3 and H4K20me3 in the context of neural stem progenitor cells
Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network
Cancer cell-derived IL-1α induces CCL22 and the recruitment of regulatory T cells
High levels of histone H3 acetylation at the CMV promoter are predictive of stable expression in Chinese hamster ovary cells
4D Visualization of replication foci in mammalian cells corresponding to individual replicons
Insights into the DNA-binding mechanism of a LytTR-type transcription regulator
A spherical harmonics intensity model for 3D segmentation and 3D shape analysis of heterochromatin foci
Interaction Analysis of a Two-Component System Using Nanodiscs
The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases
The presence of extra chromosomes leads to genomic instability
A role for tuned levels of nucleosome remodeler subunit ACF1 during Drosophila oogenesis
Combinatorial Histone Acetylation Patterns Are Generated by Motif-Specific Reactions
A Quantitative Proteomic Analysis of In Vitro Assembled Chromatin
ε-globin expression is regulated by SUV4-20h1
Heptad-Specific Phosphorylation of RNA Polymerase II CTD
Life span extension by targeting a link between metabolism and histone acetylation in Drosophila
The histone chaperone sNASP binds a conserved peptide motif within the globular core of histone H3 through its TPR repeats
Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery
Fimbrolide Natural Products Disrupt Bioluminescence of Vibrio By Targeting Autoinducer Biosynthesis and Luciferase Activity
CMV promoter mutants with a reduced propensity to productivity loss in CHO cells
Site-specific methylation and acetylation of lysine residues in the C-terminal domain (CTD) of RNA polymerase II
Structure of the RNA Helicase MLE Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling
Stall no more at polyproline stretches with the translation elongation factors EF-P and IF-5A
C-C chemokine receptor type-4 transduction of T cells enhances interaction with dendritic cells, tumor infiltration and therapeutic efficacy of adoptive T cell transfer
Versatile and Efficient Site-Specific Protein Functionalization by Tubulin Tyrosine Ligase
ATM, MacroH2A.1, and SASP: The Checks and Balances of Cellular Senescence
Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells
Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma
Designing Cell-Type-Specific Genome-wide Experiments
Phosphorylation of TET Proteins Is Regulated via O-GlcNAcylation by the O-Linked N-Acetylglucosamine Transferase (OGT)
The bacterial translation stress response
A Modular View of the Diversity of Cell-Density-Encoding Schemes in Bacterial Quorum-Sensing Systems
ISWI Remodelling of Physiological Chromatin Fibres Acetylated at Lysine 16 of Histone H4
Visualization and targeted disruption of protein interactions in living cells
Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P
Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity
Dosage compensation and the global re-balancing of aneuploid genomes
Form and function of dosage-compensated chromosomes – a chicken-and-egg relationship
Novel antibody derivatives for proteome and high-content analysis
Heterochromatin dysregulation in human diseases
Activation of Melanoma Differentiation-Associated Gene 5 Causes Rapid Involution of the Thymus
The DNA binding CXC domain of MSL2 is required for faithful targeting the Dosage Compensation Complex to the X chromosome
The multi-domain protein Np95 connects DNA methylation and histone modification
RNAPII CTD SER-7 phosphorylation is established in a mediator-dependent fashion
The regulatory interplay between membrane-integrated sensors and transport proteins in bacteria
Domain swapping reveals that the N-terminal domain of the sensor kinase KdpD in Escherichia coli is important for signaling
Nuclear Architecture of Rod Photoreceptor Cells Adapts to Vision in Mammalian Evolution
Spatiotemporal Dynamics of Regulatory Protein Recruitment at DNA Damage Sites
The Chromosomal High-Affinity Binding Sites for the Drosophila Dosage Compensation Complex
Short-term activation induces multifunctional dendritic cells that generate potent antitumor T-cell responses in vivo
Discontinuous movement of mRNP particles in nucleoplasmic regions devoid of chromatin
Combined Use of RNAi and Quantitative Proteomics to Study Gene Function in Drosophila
DNA sequence and the organization of chromosomal domains
Campus Movie 2020
Campus Movie 2012
Show Organigram
