Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals
Systematic analysis of the binding behaviourof UHRF1 towards different methyl- and carboxylcytosine modification patterns at CpG dyads
Excursion of the CIPSM Integrated Graduate Forum to the Bayer AG as part of the lecture on Innovations Management of Alumnus Bayer AG Board of Management Member Wolfgang Plischke.
HAPPY SEASONAL GREETINGS FROM CIPSM!
NAIL-MS reveals the repair of 2-methylthiocytidine by AlkB in E. coli
TLR8 Is a Sensor of RNase T2 Degradation Products
Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans
CIPSM Scientific Oktoberfest 2019
Richtfest bei unserem Institut für Chemische Epigenetik ICEM
CIPSM speaker Prof. Thomas Carell was elected to the BASF supervisory board
Characterization of a novel cytochrome cGJ as the electron acceptor of XoxF-MDH in the thermoacidophilic methanotroph Methylacidiphilum fumariolicum SolV
A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration
Impact of the lanthanide contraction on the activity of a lanthanide-dependent methanol dehydrogenase – a kinetic and DFT study
Direct evidence for hula twist and single-bond rotation photoproducts
Direct Pathway Cloning Combined with Sequence- and Ligation-Independent Cloning for Fast Biosynthetic Gene Cluster Refactoring and Heterologous Expression
Transmission of Unidirectional Molecular Motor Rotation to a Remote Biaryl Axis
ProteomeTools: Systematic characterization of 21 post-translational protein modifications by LC-MS/MS using synthetic peptides
Chemo-enzymatic Total Synthesis of Oxosorbicillinol, Sorrentanone, Rezishanones B and C, Sorbicatechol A, Bisvertinolone, and (+)-Epoxysorbicillinol
Natural Product Potential of the Genus Nocardiopsis
Indigoid Photoswitches: Visible Light Responsive Molecular Tools
Synthesis of Fluorinated Leishmania Cap Trisaccharides for Diagnostic Tool and Vaccine Development
Photoisomerization of Mono‐Arylated Indigo and Water‐Induced Acceleration of Thermal cis‐to‐trans Isomerization
Simultaneous complementary photoswitching of hemithioindigo tweezers for dynamic guest relocalization
Baubeginn unseres Institutes für Chemische Epigenetik ICEM
Complete Mechanism of Hemithioindigo Motor Rotation
Direct Pathway Cloning (DiPaC) to unlock natural product biosynthetic potential
Transforming hemithioindigo from a two-way to a one-way molecular photoswitch by isolation in the gas phase
Dual Inhibitor of Staphylococcus aureus Virulence and Biofilm Attenuates Expression of Major Toxins and Adhesins
A Pericyclic Reaction Cascade in Leporin Biosynthesis
Time-resolved infrared studies of the unfolding of a light triggered b-hairpin peptide
Conditional and Reversible Activation of Class A and B G Protein- Coupled Receptors Using Tethered Pharmacology
Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis
A sulfoxide-based isobaric labelling reagent for accurate quantitative mass spectrometry
Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase
Bap (Sil1) regulates the molecular chaperone BiP by coupling release of nucleotide and substrate
The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity
Synthesis of Double-Bond-Substituted Hemithioindigo Photoswitches
A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug‐Resistant Staphylococcus aureus
The target landscape of clinical kinase drugs
5-Formylcytosine to cytosine conversion by C–C bond cleavage in vivo
Direct Observation of Hemithioindigo-Motor Unidirectionality
Quantitative chemoproteomic profiling reveals multiple target interactions of spongiolactone derivatives in leukemia cells
Pharmacoproteomic characterisation of human colon and rectal cancer
Target and identify: triazene linker helps identify azidation sites of labelled proteins via click and cleave strategy
Structural Basis for EarP-Mediated Arginine Glycosylation of Translation Elongation Factor EF-P
Expanding the Structural Space of Ribosomal Peptides: Autocatalytic N‐Methylation in Omphalotin Biosynthesis
Hemiindigo: Highly Bistable Photoswitching at the Biooptical Window
Rational Design of an Anticalin-Type Sugar-Binding Protein Using a Genetically Encoded Boronate Side Chain
An amino acid domino effect orchestrates ClpP’s conformational states
PROCAL: A Set of 40 Peptide Standards for Retention Time Indexing, Column Performance Monitoring, and Collision Energy Calibration
Quantitative Proteomics for the Comprehensive Analysis of Stress Responses of Lactobacillus paracasei subsp. paracasei F19
A chemical compound inhibiting the Aha1-Hsp90 chaperone complex
Tight Molecular Recognition of Benzo[a]pyrene by a High‐Affinity Antibody
Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening
Stereoselective Total Synthesis of Bisorbicillinoid Natural Products by Enzymatic Oxidative Dearomatization/Dimerization
Trimodal Mixed Mode Chromatography That Enables Efficient Offline Two-Dimensional Peptide Fractionation for Proteome Analysis
Dendrimer-Based Signal Amplification of Click-Labelled DNA in Situ
5-Formyl- and 5-Carboxydeoxycytidines Do Not Cause Accumulation of Harmful Repair Intermediates in Stem Cells
Wissenschaftsrat gibt grünes Licht für den auf dem CIPSM basierenden Forschungsbau – chemische Epigenetik (ICEM)
Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation
Chemoproteomics‐Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors
Annotation of the Domestic Pig Genome by Quantitative Proteogenomics
Structural Insights into the Recognition of N2-Aryl- and C8-Aryl DNA Lesions by the Repair Protein XPA/Rad14
Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ
Two serines in the distal C-terminus of the human ß1-adrenoceptor determine ß-arrestin2 recruitment
Surface topology affects wetting behavior of Bacillus subtilis biofilms
Quantitative LC–MS Provides No Evidence for m6dA or m4dC in the Genome of Mouse Embryonic Stem Cells and Tissues
Targeted Diazotransfer Reagents Enable Selective Modification of Proteins with Azides
Chemical Probes Unravel an Antimicrobial Defense Response Triggered by Binding of the Human Opioid Dynorphin to a Bacterial Sensor Kinase
Bistable Photoswitching of Hemithioindigo with Green and Red Light: Entry Point to Advanced Molecular Digital Information Processing
Ingredients to TICT Formation in Donor Substituted Hemithioindigo
Novel Monoclonal Antibodies Recognizing Human Prostate‐Specific Membrane Antigen (PSMA) as Research and Theranostic Tools
The microstructure and micromechanics of the tendon–bone insertion
Lapatinib Resistance in Breast Cancer Cells Is Accompanied by Phosphorylation-Mediated Reprogramming of Glycolysis
Quantitative Map of β-Lactone-Induced Virulence Regulation
Building ProteomeTools based on a complete synthetic human proteome
Biocatalytic Total Synthesis of Ikarugamycin
Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone
Students of the Ernst Mach Gymnasium came to CIPSM.
Proteomics reveals a new DNA repair factor involved in DNA damage signaling
2′-(R)-Fluorinated mC, hmC, fC and caC triphosphates are substrates for DNA polymerases and TET-enzymes
Synthesis of ramariolide natural products and discovery of their targets in mycobacteria
SCAI promotes DNA double-strand break repair in distinct chromosomal contexts
Phosphoproteome Profiling Reveals Molecular Mechanisms of Growth-Factor-Mediated Kinase Inhibitor Resistance in EGFR-Overexpressing Cancer Cells
Insights into ClpXP proteolysis: Heterooligomerization and partial deactivation enhance chaperone affinity and substrate turnover in Listeria monocytogenes
Marine Fungi as Producers of Benzocoumarins, a New Class of Inhibitors of Glycogen-Synthase-Kinase 3β
Natural-Product-Inspired Aminoepoxybenzoquinones Kill Members of the Gram-Negative Pathogen Salmonella by Attenuating Cellular Stress Response
Aligning, analyzing, and visualizing sequences for antibody engineering: Automated recognition of immunoglobulin variable region features
Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs
Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs
Activation of the ATR kinase by the RPA-binding protein ETAA1
Photocontrol of Polar Aromatic Interactions by a Bis-Hemithioindigo Based Helical Receptor
Expression and purification of EPHA2 tyrosine kinase domain for crystallographic and NMR studies
Self-Assembled Palladium and Platinum Coordination Cages: Photophysical Studies and Anticancer Activity
K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria
A bead-based western for high-throughput cellular signal transduction analyses
Comparison of enzymatic properties and small molecule inhibition of γ–glutamyltranspeptidases from pathogenic and commensal bacteria
Site-Specific Isotope-Labeling of Inosine Phosphoramidites and NMR Analysis of an Inosine-Containing RNA Duplex
PASylated Coversin, a C5-Specific Complement Inhibitor with Extended Pharmacokinetics, Shows Enhanced Anti-Hemolytic Activity in Vitro
Mechanistic analysis of aliphatic β-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action
Fusion of an alcohol dehydrogenase with an aminotransferase using a PAS linker to improve coupled enzymatic alcohol-to-amine conversion
Twisted Hemithioindigo Photoswitches: Solvent Polarity Determines the Type of Light-Induced Rotations
5-Formylcytosine Could Be a Semipermanent Base in Specific Genome Sites
Synthesis of (R)-Configured 2′-Fluorinated mC, hmC, fC, and caC Phosphoramidites and Oligonucleotides
Tumour hypoxia causes DNA hypermethylation by reducing TET activity
p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1
DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy
Anticalins directed against vascular endothelial growth factor receptor 3 (VEGFR-3) with picomolar affinities show potential for medical therapy and in vivo imaging
Structural Basis for Bulky-Adduct DNA-Lesion Recognition by the Nucleotide Excision Repair Protein Rad14
Tumor uptake of anti-CD20 Fabs depends on tumor perfusion
BiPPred: Combined sequence- and structure-based prediction of peptide binding to the Hsp70 chaperone BiP
One-Pot Synthesis of Substituted Trifluoromethylated 2,3-Dihydro-1H-imidazoles
Synthesis of a Fluorinated Sialophorin Hexasaccharide–Threonine Conjugate for Fmoc Solid-Phase Glycopeptide Synthesis
Immunomodulatory drugs disrupt the cereblon–CD147–MCT1 axis to exert antitumor activity and teratogenicity
Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation
ANTICALIgN: visualizing, editing and analyzing combined nucleotide and amino acid sequence alignments for combinatorial protein engineering
A high-yielding, strictly regioselective prebiotic purine nucleoside formation pathway
MALDI-TOF and nESI Orbitrap MS/MS identify orthogonal parts of the phosphoproteome
High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer β-amyloid peptide
Structural basis for cellulose binding by the type A carbohydrate-binding module 64 of Spirochaeta thermophila
Active DNA demethylation at enhancers during the vertebrate phylotypic period
Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release
Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors
Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores
Molecular mechanisms of xeroderma pigmentosum (XP) proteins
Convenient Access to Di- and Trifluoroethylamines for Lead Structure Research
Towards Understanding Male Infertility After Spinal Cord Injury Using Quantitative Proteomics
One-Pot Synthesis of Functionalized β-Fluoroalkylated Mannich- Type Products from N-Aryl N,O-Acetals
Sequential Inactivation of Gliotoxin by the S-Methyltransferase TmtA
Selection and characterization of Anticalins targeting human prostate-specific membrane antigen (PSMA)
Making a Long Journey Short: Alkyne Functionalization of Natural Product Scaffolds
An Aromatic Hydroxyamide Attenuates Multiresistant Staphylococcus aureus Toxin Expression
TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress
Season's Greetings and Best Wishes for a Happy New Year 2016 from CIPSM
moCluster: Identifying Joint Patterns Across Multiple Omics Data Sets
Optical Control of Insulin Secretion Using an Incretin Switch
Extending Polyketide Structural Diversity by Using Engineered Carboxylase/Reductase Enzymes
UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair
Fimbrolide Natural Products Disrupt Bioluminescence of Vibrio By Targeting Autoinducer Biosynthesis and Luciferase Activity
Barrel-shaped ClpP Proteases Display Attenuated Cleavage Specificities
CIPSM in ARD & BR alpha television
Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association
Optische Kontrolle der Insulinsekretion mit einem Inkretinschalter
Long-Acting PASylated Leptin Ameliorates Obesity by Promoting Satiety and Preventing Hypometabolism in Leptin-Deficient Lepob/ob Mice
Molecular mechanisms behind the antimicrobial activity of hop iso-α-acids in Lactobacillus brevis
Anticalins directed against the fibronectin extra domain B as diagnostic tracers for glioblastomas
Sunlight-powered kHz rotation of a hemithioindigo-based molecular motor
Optimisation of a system for the co-translational incorporation of a keto amino acid and its application to a tumour-specific Anticalin
Evaluation of Kinase Activity Profiling Using Chemical Proteomics
Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogue
CRISPR-Cas: From the Bacterial Adaptive Immune System to a Versatile Tool for Genome Engineering
Engineering of alanine dehydrogenase from Bacillus subtilis for novel cofactor specificity
Alkynol natural products target ALDH2 in cancer cells by irreversible binding to the active site
Stability engineering of the Geobacillus stearothermophilus alcohol dehydrogenase and application for the synthesis of a polyamide 12 precursor
Kinetic and Theoretical Studies of Beta-Lactone Reactivity—A Quantitative Scale for Biological Application
Hemithioindigo—an emerging photoswitch
Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA)
Age-Dependent Levels of 5-Methyl-, 5-Hydroxymethyl-, and 5-Formylcytosine in Human and Mouse Brain Tissues
Semi-supervised Learning Predicts Approximately One Third of the Alternative Splicing Isoforms as Functional Proteins
Dewar Lesion Formation in Single- and Double-Stranded DNA is Quenched by Neighboring Bases
Inhibitor-based affinity probes for the investigation of JAK signaling pathways
Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma
89Zr-Labeled Versus 124I-Labeled αHER2 Fab with Optimized Plasma Half-Life for High-Contrast Tumor Imaging In Vivo
A Scalable Approach for Protein False Discovery Rate Estimation in Large Proteomic Data Sets
Chemical Proteomics Uncovers EPHA2 as a Mechanism of Acquired Resistance to Small Molecule EGFR Kinase Inhibition
Widespread Proteome Remodeling and Aggregation in Aging C. elegans
Crystal structure of the human odorant binding protein, OBPIIa
Orchestrating the Biosynthesis of an Unnatural Pyrrolysine Amino Acid for Its Direct Incorporation into Proteins Inside Living Cells
PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy
The Menagerie of Human Lipocalins: A Natural Protein Scaffold for Molecular Recognition of Physiological Compounds
AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control
Optimized Chemical Proteomics Assay for Kinase Inhibitor Profiling
Synthesis and biological evaluation of a novel MUC1 glycopeptide conjugate vaccine candidate comprising a 4’-deoxy-4’-fluoro-Thomsen–Friedenreich epitope
Homology-driven assembly of NOn-redundant protEin sequence sets (NOmESS) for mass spectrometry
The dimeric crystal structure of the human fertility lipocalin glycodelin reveals a protein scaffold for the presentation of complex glycans
Design and Characterization of a Modular Membrane Protein Anchor to Functionalize the Moss Physcomitrella patens with Extracellular Catalytic and/or Binding Activities
DNA methylation and differential gene regulation in photoreceptor cell death
Disruption of the PRKCD–FBXO25–HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis
High contrast tumor imaging with radio-labeled antibody Fab fragments tailored for optimized pharmacokinetics via PASylation
Comprehensive and Reproducible Phosphopeptide Enrichment Using Iron Immobilized Metal Ion Affinity Chromatography (Fe-IMAC) Columns
Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics
Investigating RET RTK Signaling Pathways Using an IAP-Based Activity-Profiling Approach
Antibody Recognition of Fluorinated Haptens and Antigens
Amythiamicin D and Related Thiopeptides as Inhibitors of the Bacterial Elongation Factor EF-Tu: Modification of the Amino Acid at Carbon Atom C2 of Ring C Dramatically Influences Activity
A large synthetic peptide and phosphopeptide reference library for mass spectrometry–based proteomics
Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency
A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity
In vitro Percutaneous Absorption of 14C-Labeled β-Lactone Promises Topical Delivery of New Bacterial Virulence Inhibitors
Structure and Function of Noncanonical Nucleobases
Dynamics of ultraviolet-induced DNA lesions: Dewar formation guided by pre-tension induced by the backbone
Radiolabelled RGD peptides for imaging and therapy
Low values of 5-hydroxymethylcytosine (5hmC), the ‘‘sixth base,’’ are associated with anaplasia in human brain tumors
Beta-Lactams and Beta-lactones as activity-based probes in chemical biology
The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity
Protein Reactivity of Natural Product-Derived γ-Butyrolactones
Biosynthesis of Isoprenoids: Crystal Structure of the [4Fe–4S] Cluster Protein IspG
Mechanism of replication blocking and bypass of Y-family polymerase Eta by bulky acetylaminofluorene DNA adducts
Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner
Confident phosphorylation site localization using the Mascot Delta Score
Residue-Specific Side-Chain Packing Determines the Backbone Dynamics of Transmembrane Model Helices
Reductive Dehydroxylation of Allyl Alcohols by IspH Protein
Biomimetic Synthesis of (−)-Pycnanthuquinone C through the Diels–Alder Reaction of a Vinyl Quinone
Convergent Synthesis and Biological Evaluation of Syringolin A and Derivatives as Eukaryotic 20S Proteasome Inhibitors
Proteomics: a pragmatic perspective
The 26S proteasome: assembly and function of a destructive machine
Showdomycin as a Versatile Chemical Tool for the Detection of Pathogenesis-Associated Enzymes in Bacteria
Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies
DNA (6-4) Photolyases Reduce Dewar Isomers for Isomerization into (6-4) Lesions
Combination of FASP and StageTip-Based Fractionation Allows In-Depth Analysis of the Hippocampal Membrane Proteome
Parallel Isotope-Based Quantification of Modified tRNA Nucleosides
NMR Structure and Dynamics of the Engineered Fluorescein-Binding Lipocalin FluA Reveal Rigidification of β-Barrel and Variable Loops upon Enthalpy-Driven Ligand Binding
The archaeal cofactor F0 is a light-harvesting antenna chromophore in eukaryotes
Copper-Free “Click” Modification of DNA via Nitrile Oxide-Norbornene 1,3-Dipolar Cycloaddition
Imaging of integrin alpha-v-beta-3 expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography
Phosphorothioation of Oligonucleotides Strongly Influences the Inhibition of Bacterial (M.HhaI) and Human(Dnmt1) DNA Methyltransferases
Importin 8 Is a Gene Silencing Factor that Targets Argonaute Proteins to Distinct mRNAs
The persisting challenge of selective and specific proteasome inhibition
Complex patterns of histidine, hydroxylated amino acids and the GxxxG motif mediate high-affinity transmembrane domain interactions
Secondary structure and distribution of fusogenic LV-peptides in lipid membranes
CPD Damage Recognition by Transcribing RNA Polymerase II
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